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Citing the observation that spaying causes female animals to stop mating in the same species as castration cause male animals to stop mating, and that in the animal species where females continue their mating behavior after being spayed the males also continue to mate after being castrated, there are scientists who argue that it makes no biological sense to assume that any treatment that emulates castration would remove sex drive in men but not in women.
These scientists argue that these observations, along with the fact that humans are animals and subject to evolution, show that it is flawed to think that male sexuality would be treatable by medication if female sexuality is not.
After the outrage following the gang rape of a woman in Delhi, the Government has submitted a draft proposing chemical castration along with an imprisonment of up to 30 years for rape convicts as part of the anti-rape law in India.
The ministry is preparing a detailed bill and the recommended changes are under review.
Some criminologists argue that the appearance of a lower recidivism rate in male sex offenders who take chemical castration treatment than in those who do not can be explained by factors other than biological effects of the medication.
One hypothesis is that men who accept the negative effects of hormonal treatment in exchange for shorter prison sentence are distinct in that they value freedom from incarceration higher than men who rather stay in prison for a longer time than face the side effects of chemical castration.
In 2008, an experimental intervention program was launched in three Portuguese prisons: Carregueira (Belas, Sintra), Paços de Ferreira and Funchal.
The program developers note the voluntary nature of the program a crucial factor in its success.
One of the accused in the rape case is a juvenile and aged a few months less than 18 years.
A view has been expressed by a section that only those below 15 years should be described as juvenile.
In 2016, the Indonesian President Joko Widodo introduced a presidential regulation allowing for chemical castration to be handed down as a punishment to child sex offenders and pedophiles.
Life-threatening side effects are rare, but some users show increases in body fat and reduced bone density, which increase long-term risk of cardiovascular disease and osteoporosis.
They may also experience gynecomastia (development of larger than normal mammary glands in males) as seen in Alan Turing's case.